Elisabeth Barton joined APK in 2015. She is a molecular physiologist with a primary interest in skeletal muscle repair. Her work has broad applications including accelerating the resolution of muscle damage after acute injuries, altering the balance between damage and repair in chronic injury associated with neuromuscular disease, and enhancing the repair axis in aging muscle. She has spent the last 20 years studying insulin-like growth factor I (IGF-I), a key player in the muscle regeneration process. More recently, Barton has focused on how muscles sense load, and how these sensors become dysfunctional in muscle disease. Her research has been supported by grants from NIH, NASA, Muscular Dystrophy Association, and the DOD.
In addition to her own research program, Barton has served as the Director of the Physiological Assessment Core in the Paul D. Wellstone Muscular Dystrophy Cooperative Research Center since its inception. The core, which has also moved to the University of Florida has evaluated muscle function in several mouse lines with subtle and dramatic phenotypes, supported investigators from academia and industry, and developed and optimized several outcomes measures to assess force generation capacity and fragility in murine muscles.