Fatigue & Underlying Neurobiology Lab
Transforming how fatigue is understood and treated through interdisciplinary, patient-centered research.
Why we care
Fatigue robs millions of people of their ability to think clearly, move easily, and fully participate in life. It is one of the most prevalent and disabling symptoms across neurological, psychiatric, and other chronic illnesses; yet it remains poorly understood and inadequately treated. We believe no one should have to live with the burden of unexplained and untreated fatigue.
How we tackle the problem
Our work begins with a simple but transformative idea: fatigue is not a single, uniform phenomenon. It is a multidimensional phenomenon, with distinct features, each driven by unique neurobiological mechanisms. By merging these features into one imprecise construct, traditional approaches have obscured our understanding and hindered the development of effective treatments. We aim to transform how fatigue is understood, studied, and treated by clearly defining its features, then investigating each through a rigorous, interdisciplinary approach. Our research combines motor, cognitive, and decision neuroscience with neuroimaging, psychophysiology, wearable technologies, and real-world assessments. We work side-by-side with scientists across disciplines, clinicians, engineers, and -most importantly- patients to ensure our discoveries are both innovative and clinically meaningful.
What we do
Our research program aims to:
- Identify the distinct behavioral features of fatigue through integrative testing in laboratory and real-world settings.
- Uncover the unique neurobiological mechanisms underlying each feature using state-of-the-art neuroimaging and physiological methods.
- Develop targeted, evidence-based interventions, including non-invasive brain stimulation and rehabilitation strategies.
Every step of our work is guided by a culture of teamwork, respect, curiosity, and determination. We value diverse perspectives and believe that true scientific breakthroughs happen when discovery is a collective effort. Our ultimate goal is to translate research into effective care, thereby transforming how fatigue is understood, diagnosed, and treated, and improving the quality of life of the millions of individuals suffering from fatigue.
- Principal Investigator: Agostina Casamento-Moran, Ph.D.
- Publications: Google Scholar