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Biography

Terence E. Ryan, Ph.D. is an Associate Professor in the department of Applied Physiology & Kinesiology. As a Principal Investigator, he is focused on understanding the molecular pathways that regulate muscle and vascular responses to environmental and endogenous stressors (both physiological and pathological). Because cellular life emanates from the ability of our cells to establish and hold an energy (ATP/ADP) charge, a major focus of his lab is the role of cellular and mitochondrial energetics in cellular function. Mitochondria have demonstrated roles not only in energetics (i.e. ATP production), but also redox biology, cellular signaling, as well as cellular growth/differentiation and cell death.  Throughout the course of his academic and research training, Dr. Ryan has acquired a wealth of laboratory techniques and experimental models to study mitochondrial and cellular biology in cells, pre-clinical research models, as well as clinical studies in human patients.  He joined the University of Florida after completing postdoctoral training in Mitochondrial Biology at the East Carolina Diabetes and Obesity Institute within the Brody School of Medicine at East Carolina University. Current work in his lab aims to decipher the mechanisms by which cellular metabolism and mitochondria regulate pathologic burden, muscle regeneration, and angiogenesis.  Work in Dr. Ryan’s lab is supported by grants from the American Heart Association and the NIH.  

Research Interests

• Mitchondrial bioenergetics
• Redox biology
• Skeletal muscle regeneration
• Angiogenesis & neovascularization
• Engineering gene therapies for the treatment of chronic disease